Joseph C. Madara

A hypothalamic circuit for anticipating future changes in energy balance.

The paper shows that environmental cues predicting future fasting rapidly activate AgRP neurons via a circuit involving PVHSim2 neurons.

Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days

The paper investigates how dopamine transmission and mating drive change over days in male mice, finding two mechanisms that regulate these slow-timescale dynamics.

Competition between stochastic neuropeptide signals calibrates the rate of satiation

The paper shows how stochastic neuropeptide signals (NPY and MSH) compete to regulate cAMP levels in neurons, influencing satiation through state-dependent integration.

Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons tosuppress feeding

The paper shows that transient cAMP production in brainstem parabrachial neurons suppresses feeding for minutes, matching the duration of cAMP and calcium activity elevations.

PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

This study identifies PACAP-expressing neurons in the ventral premammillary nucleus that regulate reproductive function in female mice by modulating kisspeptin neurons.