Author

Simone Wahl

Helmholtz Munich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:Bayesian inference· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Annette PetersiD· 3 shared Christian GiegeriD· 3 shared Konstantin StrauchiD· 3 shared Mélanie WaldenbergeriD· 3 shared Sonja KunzeiD· 3 shared Fabian Joachim TheisiD· 2 shared Harald GrallertiD· 2 shared Alexis J. BattleiD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBioinformatics

Annette PetersORCID

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Author profile →

4 papers

Recent·Most cited

Network reconstruction for trans acting genetic loci using multi-omics data and prior information

Johann S. Hawe, Ashis Saha, Mélanie Waldenberger, Sonja Kunze, Simone Wahl, Martina Müller‐Nurasyid, Holger Prokisch, Harald Grallert, Christian Herder, Annette Peters, Konstantin Strauch, Fabian Joachim Theis, Christian Gieger, John Campbell Chambers, Alexis J. Battle, Matthias Heinig

The paper reconstructs regulatory networks underlying trans-QTL hotspots using human multi-omics data and biological priors, identifying novel networks related to schizophrenia and lean body mass.

Genome Medicine · Nov 7, 2022Peer-reviewedBioinformatics

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

Stefan Coassin, Natascha Hermann‐Kleiter, Margot Haun, Simone Wahl, Rory Wilson, Bernhard Paulweber, Sonja Kunze, Thomas Meitinger, Konstantin Strauch, Annette Peters, Mélanie Waldenberger, Florian Kronenberg, Claudia Lamina

The paper identifies a DNA methylation site in the LPA promoter associated with Lp(a) levels and shows that a SNP at this site influences Lp(a) through direct genetic effect, not methylation.

PLoS ONE · Apr 28, 2020Peer-reviewedGenetics

Epigenetic derepression of FKBP5 by aging and stress contributes to NF-kB-driven inflammation and cardiovascular risk

Anthony S. Zannas, Meiwen Jia, Kathrin Hafner, Jens J Baumert, Tobias Wiechmann, Julius C. Pape, Janine Arloth, Maik Ködel, Silvia Martinelli, Maria Roitman, Simone Röh, Andreas Haehle, Rebecca T. Emeny, Stella Iurato, Tania Carrillo‐Roa, , Elisabeth B. Binder

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.

bioRxiv · Dec 3, 2018 · PreprintGenomics

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

Kieu Trinh Do, Simone Wahl, Johannes Raffler, Sophie Molnos, Michael Laimighofer, Jerzy Adamski, Karsten Suhre, Konstantin Strauch, Annette Peters, Christian Gieger, Claudia Langenberg, Isobel D. Stewart, Fabian Joachim Theis, Harald Grallert, Gabi Kastenmüller, Jan Krumsiek

The paper evaluates missing data handling strategies in untargeted metabolomics data, finding that KNN imputation with variable pre-selection is robust across multiple evaluation schemes.

Metabolomics · Sep 20, 2018Peer-reviewedSystems Biology