Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions
Xiaowei Jin, Jordan Rosenbohm, Eunju Kim, Bahareh Tajvidi Safa, Amir Ostadi Moghaddam, Kristina Seiffert-Sinha, Merced Leiker, Elijah Jones, Haiwei Zhai, Sindora R. Baddam, Grayson Minnick, Yucheng Huo, James K. Wahl, Fanben Meng, Changjin Huang, , Ruiguo Yang
This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.
iScience · Jul 15, 2025Peer-reviewedBiophysics