Nicotinamide riboside alleviates Parkinson's disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure
Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Loge Nilsen, Jaan‐Olle Andressoo, Eija Pirinen
This study shows that nicotinamide riboside (NR) alleviates Parkinson's disease symptoms in animal models but reduces dopamine levels when combined with proteasome inhibition.
bioRxiv · Mar 12, 2021 · PreprintNeuroscience