Jaan‐Olle Andressoo

A Fast Approach for Structural and Evolutionary Analysis Based on Energetic Profile Protein Comparison

This paper introduces an energy profile-based method for rapid structural and evolutionary protein analysis, showing it can distinguish proteins across species and correlate with network-based approaches.

Serotonin system development and adult function are regulated by GDNF

This study shows that GDNF regulates serotonin system development and adult function, with excess GDNF linked to neuropsychiatric disorders.

Motor learning is regulated by GDNF levels in postnatal cerebellar Purkinje cells

This study shows that increasing GDNF in postnatal Purkinje cells enhances motor learning in mice, with findings relevant to human motor skill differences.

Nicotinamide riboside alleviates Parkinson's disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure

This study shows that nicotinamide riboside (NR) alleviates Parkinson's disease symptoms in animal models but reduces dopamine levels when combined with proteasome inhibition.

Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF

This study shows that excess fetal GDNF can prolong nephrogenesis in postnatal mouse kidneys without increasing tumor risk.

Gene Knock Up via 3’UTR editing to study gene function in vivo

This paper develops methods to upregulate gene expression in vivo while preserving cell-type-specific regulation, demonstrating their use in studying gene function and disease mechanisms.