Eija Pirinen

This study shows that loss of GRPEL2 in mice protects against age- and diet-induced obesity and improves metabolic health without affecting mitochondrial protein import.

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

This study shows chemotherapy causes NAD+ loss in muscle and liver, with Nrk2 downregulation linked to muscle wasting across multiple models.

The paper develops an in vitro model of human subcutaneous adipocyte spheroids to study mitochondrial dysfunction and test mitochondria-activating compounds in obesity.

This study shows that niacin replenishes NAD+ levels, improves mitochondrial function, and reduces cachexia in cancer models and patients.

This study shows that nicotinamide riboside (NR) alleviates Parkinson's disease symptoms in animal models but reduces dopamine levels when combined with proteasome inhibition.