Weiliang Song

Mouse V(D)J Humanization Recapitulates human-like Severe SARS-CoV-2 Immune Imprinting

This study shows that V(D)J-humanized mice can replicate severe SARS-CoV-2 immune imprinting in humans, revealing that pre-existing antibody abundance influences imprinting severity.

Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1

SARS-CoV-2 variant BA.3.2 strongly evades neutralizing antibodies but exhibits low infectivity due to a closed spike conformation, whereas NB.1.8.1 combines high ACE2 affinity with humoral immune escape.

Virological and antigenic characteristics of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1

The paper analyzes virological and antigenic traits of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1, finding trade-offs between immune evasion and ACE2 binding efficiency.

Enhanced immune evasion of SARS-CoV-2 KP.3.1.1 and XEC through NTD glycosylation

This study shows that SARS-CoV-2 variants KP.3.1.1 and XEC have enhanced immune evasion through NTD glycosylation, despite maintaining high ACE2 binding and infectivity.

Highly Accurate Non-Invasive Preimplantation Genetic Testing for Monogenic and Polygenic Diseases from Spent Medium

This paper presents a non-invasive preimplantation genetic testing method using spent embryo culture medium, achieving high accuracy for monogenic and polygenic disease detection without modifying IVF workflows.

Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

The paper investigates how Omicron-specific naive B cell maturation after breakthrough infection alleviates immune imprinting from inactivated SARS-CoV-2 vaccines.

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

Single-cell bisulfite-free 5mC and 5hmC sequencing with high sensitivity and scalability

The paper introduces Cabernet, a bisulfite-free single-cell method for high-resolution 5mC and 5hmC profiling, revealing epigenetic dynamics in mouse embryos and demonstrating scalability for complex tissues.