Author

Sofia E. Sepulveda

The University of Texas Health Science Center at Houston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Andi LiuiD· 1 shared Astrid Marilyn ManueliD· 1 shared Brisa Simões FernandesiD· 1 shared Chia-Hao TungiD· 1 shared Citu CituiD· 1 shared Claudio A. SotoiD· 1 shared Damian GorskiiD· 1 shared Lukas Mikolaj SimoniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Andi LiuORCID

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1 paper

Recent·Most cited

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease

Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E. Sepulveda, Astrid Marilyn Manuel, Damian Gorski, Brisa Simões Fernandes, Meifang Yu, Paul Ernest Schulz, Lukas Mikolaj Simon, Claudio A. Soto, Zhongming Zhao

This study creates a single-nucleus multiome atlas of sEOAD brain regions, identifying key transcription factors and regulatory elements linked to disease.

Science Advances · Dec 17, 2025Peer-reviewedNeuroscience