Author

Brisa Simões Fernandes

The University of Texas Health Science Center at HoustonORCID 0000-0002-3797-7582Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Zhongming ZhaoiD· 3 shared Andi LiuiD· 2 shared Astrid Marilyn ManueliD· 2 shared Chia-Hao TungiD· 1 shared Citu CituiD· 1 shared Claudio A. SotoiD· 1 shared Damian GorskiiD· 1 shared Guangsheng PeiiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Zhongming ZhaoORCID

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3 papers

Recent·Most cited

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease

Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E. Sepulveda, Astrid Marilyn Manuel, Damian Gorski, Brisa Simões Fernandes, Meifang Yu, Paul Ernest Schulz, Lukas Mikolaj Simon, Claudio A. Soto, Zhongming Zhao

This study creates a single-nucleus multiome atlas of sEOAD brain regions, identifying key transcription factors and regulatory elements linked to disease.

Science Advances · Dec 17, 2025Peer-reviewedNeuroscience

GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases

Xiaoyang Li, Brisa Simões Fernandes, Andi Liu, Jingchun Chen, Xiangning Chen, Zhongming Zhao, Yulin Dai

GRPa-PRS identifies genetically-regulated pathways in polygenic diseases by stratifying individuals based on PRS and analyzing differential gene expression across risk strata.

Alzheimer s & Dementia · Oct 1, 2025Peer-reviewedGenetic & Genomic Medicine

A single-cell atlas of the human brain in Alzheimer's disease and its implications for personalized drug repositioning

Guangsheng Pei, Brisa Simões Fernandes, Yin‐Ying Wang, Astrid Marilyn Manuel, Peilin Jia, Zhongming Zhao

This paper constructs a single-cell atlas of Alzheimer's disease brain tissue and identifies drug repositioning candidates by analyzing cellular heterogeneity and gene expression patterns.

bioRxiv · Jun 14, 2022 · PreprintBioinformatics