Xian Chen

This study creates a single-nucleus multiome atlas of sEOAD brain regions, identifying key transcription factors and regulatory elements linked to disease.

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

The paper provides comprehensive reference materials with genomic, epigenomic, transcriptomic, scRNA-seq, and proteomic characterizations of two cell lines for benchmarking and validation.