Assessment of polymeric immunoglobulin A and M via detection of the joining chain
Nienke Oskam, Jim B. D. Keijser, Marij Streutker, Sofie Keijzer, Pleuni Ooijevaar‐de Heer, Gerard J. van Mierlo, Ninotska I. L. Derksen, T2B! immunity against SARS‐CoV‐2 study group, Gestur Vidarsson, Theo Rispens
This paper develops sensitive ELISAs to quantify J-chain-containing IgA and IgM, revealing that 10% of circulating IgA is polymeric and enabling high-throughput analysis of polymeric IgA responses.
bioRxiv · Jul 16, 2026 · PreprintImmunology