Author

Gerard J. van Mierlo

Amsterdam UMC Location University of Amsterdam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Gestur VidarssoniD· 2 shared Marij Streutker· 2 shared Nienke OskamiD· 2 shared Ninotska I. L. DerkseniD· 2 shared Pleuni Ooijevaar‐de HeeriD· 2 shared Theo RispensiD· 2 shared Albert BondtiD· 1 shared Albert J. R. HeckiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

Gestur VidarssonORCID

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Author profile →

3 papers

Recent·Most cited

Assessment of polymeric immunoglobulin A and M via detection of the joining chain

Nienke Oskam, Jim B. D. Keijser, Marij Streutker, Sofie Keijzer, Pleuni Ooijevaar‐de Heer, Gerard J. van Mierlo, Ninotska I. L. Derksen, T2B! immunity against SARS‐CoV‐2 study group, Gestur Vidarsson, Theo Rispens

This paper develops sensitive ELISAs to quantify J-chain-containing IgA and IgM, revealing that 10% of circulating IgA is polymeric and enabling high-throughput analysis of polymeric IgA responses.

bioRxiv · Jul 16, 2026 · PreprintImmunology

CD5L is a canonical component of circulatory IgM

Nienke Oskam, Maurits A. den Boer, Marie Vestergaard Lukassen, Pleuni Ooijevaar‐de Heer, Tim S. Veth, Gerard J. van Mierlo, Szu‐Hsueh Lai, Ninotska I. L. Derksen, Victor C. Yin, Marij Streutker, Vojtěch Franc, Marta Šiborová, Mirjam J. A. Damen, Dorien Kos, Arjan Barendregt, , Albert J. R. Heck

The paper identifies CD5L as a component of circulatory IgM, showing it forms a complex with J-chain-containing pentamers and affects IgM receptor binding.

Proceedings of the National Academy of Sciences · Dec 6, 2023Peer-reviewedMolecular Biology

Optimized guide RNA selection recommendations for using spCas9 gene editing in human hematopoietic stem and progenitor cells

Han J. M. P. Verhagen, Carlijn Kuijk, Anne M. Kokke, Laurens Rutgers, Santhe A. van der Meulen, Gerard J. van Mierlo, Carlijn Voermans, Emile van den Akker

The paper evaluates sgRNA design for spCas9-RNP gene editing in HSPCs, showing in vitro screening outperforms in silico models and no adverse effects on cell function.

bioRxiv · Dec 18, 2020 · PreprintMolecular Biology