Oxidative Injury to Lung Mitochondrial DNA is a Key Contributorfor the Development of Chemical Lung Injury
Shubham Dubey, Zhihong Yu, Emily Morgan Stephens, Ahmed Lazrak, Israr Ahmad, Saurabh Aggarwal, Shaida A. Andrabi, Mohammed Iqbal Hossain, Tamás Jilling, Solana Fernandez, Jennifer L. Bartels, Suzanne E. Lapi, James A. Mobley, Viktor M. Pastukh, Mark N. Gillespie, Sadis Matalon
This study shows that oxidative injury to mitochondrial DNA contributes to acute and chronic lung injury, and that targeting OGG1 can mitigate this damage.
Redox Biology · Mar 31, 2025Peer-reviewedPhysiology