Shaida A. Andrabi

Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with alpha-Synucleinopathy

This study shows that activating RXR reduces alpha-synuclein pathology and neuroinflammation in a mouse model of Parkinson's disease.

Inhibition of the RNA Regulator HuR mitigates spinal cord injury by potently suppressing post-injury neuroinflammation

This study shows that inhibiting HuR with SRI-42127 reduces neuroinflammation and improves functional outcomes after spinal cord injury.

Sulfotransferase 4A1 (SULT4a1): A Novel Neuroprotective Protein in Stroke

This study investigates the neuroprotective role of SULT4a1 in stroke, showing that it protects neurons by maintaining mitochondrial function and reducing oxidative stress in experimental models.

Oxidative Injury to Lung Mitochondrial DNA is a Key Contributorfor the Development of Chemical Lung Injury

This study shows that oxidative injury to mitochondrial DNA contributes to acute and chronic lung injury, and that targeting OGG1 can mitigate this damage.

The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity

This study identifies FGF21 as a biomarker in ALS associated with slower disease progression and protective effects against stress-induced cytotoxicity.

Poly(ADP-ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation

This study investigates how PARP-1 activation and PAR binding to HK-1 impair glycolysis, mitochondrial function, and redox balance in neurons under oxygen-glucose deprivation.

Characterization and Preclinical Treatment of Rotational Force-Induced Brain Injury

This study develops a rodent model of rotational head trauma, identifies Cdk5 as a key mediator, and shows its inhibition reduces cognitive and pathological effects.