James A. Mobley

Hyaluronic Acid Plays Differential Molecular Weight and Concentration Dependent Pathway Centric Changes to Human Lung Derived Microvascular Endothelial Cells in Culture

This study investigates how different molecular weights and concentrations of hyaluronic acid (HA) affect signaling pathways in human lung microvascular endothelial cells, revealing distinct molecular and functional responses.

Glutamine deficiency enhances nuclear localization of TCA cycle enzymes and epigenetic modifications, impairing myogenesis

This study shows that glutamine deficiency reduces MPC proliferation by altering TCA cycle enzyme localization and epigenetic modifications, impairing myogenesis.

Venom vesicles from the parasitoid Ganaspis hookeri facilitate venom protein entry into host immune cells

The paper investigates how venom vesicles from Ganaspis hookeri parasitoid wasps facilitate the entry of venom proteins, including SERCA, into host immune cells to suppress immune responses.

Oxidative Injury to Lung Mitochondrial DNA is a Key Contributorfor the Development of Chemical Lung Injury

This study shows that oxidative injury to mitochondrial DNA contributes to acute and chronic lung injury, and that targeting OGG1 can mitigate this damage.

Decreased Extracellular Vesicle Vasorin in Severe Preeclampsia Plasma Mediates Endothelial Dysfunction

This paper identifies decreased vasorin (VASN) in extracellular vesicles (EV) of severe preeclampsia (sPE) plasma as a mediator of endothelial dysfunction, showing VASN's role in vascular function and its potential as a biomarker and therapeutic target.

Glucose-Sensing ChREBP Protein in the Pathogenesis of Diabetic Retinopathy

This study investigates the role of ChREBP in diabetic retinopathy, finding its overexpression leads to metabolic reprogramming and retinal dysfunction in mice.

Comparative Proteomic Study of Retinal Ganglion Cells Undergoing Various Types of Cellular Stressors

This study compares proteomic changes in retinal ganglion cells under glutamate excitotoxicity and optic nerve crush, identifying unique and shared alterations in protein profiles.

The SARS-CoV-2 Spike S1 Protein Induces Global Proteomic Changes in ATII-Like Rat L2 Cells that are Attenuated by Hyaluronan

This study identifies global proteomic changes induced by SARS-CoV-2 Spike S1 protein in rat cells and shows that hyaluronan reduces these effects.