Pathological tau activates inflammatory nuclear factor-kappa B (NF-κB) and pT181-Qβ vaccine attenuates NF-κB in PS19 tauopathy mice
Karthikeyan Tangavelou, Shanya Jiang, Somayeh Dadras, Jonathan P. Hulse, Kathryn E. Sánchez, Virginie Bondu, Zachary Villaseñor, Michael A. Mandell, Julianne Peabody, Bryce Chackerian, Kiran Bhaskar
The paper shows that pathological tau activates NF-κB in microglia and that a pT181-Qβ vaccine reduces NF-κB activity in tauopathy mice.
bioRxiv · Mar 10, 2025 · PreprintNeuroscience