Virginie Bondu

The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neurons

This study shows OTULIN regulates tau expression and RNA metabolism in neurons, with implications for Alzheimer's disease and tauopathies.

Pathological tau activates inflammatory nuclear factor-kappa B (NF-κB) and pT181-Qβ vaccine attenuates NF-κB in PS19 tauopathy mice

The paper shows that pathological tau activates NF-κB in microglia and that a pT181-Qβ vaccine reduces NF-κB activity in tauopathy mice.