Kiran Bhaskar

This study shows OTULIN regulates tau expression and RNA metabolism in neurons, with implications for Alzheimer's disease and tauopathies.

The paper shows that pathological tau activates NF-κB in microglia and that a pT181-Qβ vaccine reduces NF-κB activity in tauopathy mice.

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

This study compares two VLP-based vaccines targeting different pTau epitopes, finding that the PHF1 vaccine reduces tau pathology and restores cognition better than the AT8 vaccine in a mouse model.

This study uses optogenetic control of TFEB to reduce pathological tau in human iPSC-neurons derived from AD patients.