Author

Sonia Okekenwa

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:contrastive learning· 1

Frequent Co-Authors

Yuyu SongiD· 3 shared Bin WangiD· 1 shared Bradley T. HymaniD· 1 shared Cameron Donahue· 1 shared Craig D. BlackstoneiD· 1 shared Etash Bhat· 1 shared Florian GeorgescauldiD· 1 shared Gerardo A. MorfiniiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Yuyu SongORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dynamic conformational ensembles of soluble Tau encode neuronal toxicity prior to aggregation

Florian Georgescauld, Sonia Okekenwa, Tanner Boyd, Cameron Donahue, Noé Quittot, John R. Dickson, Zhanyun Fan, Scott Brady, Craig D. Blackstone, Bradley T. Hyman, Yuyu Song

This study identifies dynamic conformational states of soluble Tau that precede aggregation and correlate with neuronal toxicity in Alzheimer's disease and related tauopathies.

bioRxiv · Jan 27, 2026 · PreprintNeuroscience

Lightweight open-source fine-tuning of SAM2 enables domain-specific microscopy segmentation

Etash Bhat, Sharvaa Selvan, Sonia Okekenwa, Zareh Dechkounian, Vivian Lin, Mariko Nakano-Miyatake, Mitul Saha, Yuyu Song

This paper introduces a lightweight, open-source method to fine-tune SAM2 for microscopy segmentation, achieving high accuracy with small datasets and cross-domain generalization.

bioRxiv · Nov 8, 2025 · PreprintCell Biology

Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide Repeats

Sonia Okekenwa, Ming Ying Tsai, Patrick M. Dooley, Bin Wang, Priscila Comassio, Jorge E. Moreira, Nicola G. Kriefall, Sarah Y. Martin, Gerardo A. Morfini, Scott T. Brady, Yuyu Song

This study identifies compartment-specific toxic effects of C9ORF72-derived dipeptide repeats (DPRs) in neurodegenerative disease models, revealing two distinct pathogenic mechanisms contributing to ALS and FTD.

bioRxiv · Sep 28, 2023 · PreprintNeuroscience