Author

Zhanyun Fan

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:imaging· 1

Frequent Co-Authors

Bradley T. HymaniD· 3 shared Adriano AguzziiD· 1 shared Alberto Serrano‐PozoiD· 1 shared Alessandra Carrella· 1 shared Alessandro CrimiiD· 1 shared Alexandre P. A. TheocharidesiD· 1 shared Andra ChincisaniD· 1 shared Andreia D. MagalhãesiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Bradley T. HymanORCID

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4 papers

Recent·Most cited

Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variants

Rosemary J. Jackson, Steven E. Dierksmeier, Maryam A. Nishtar, Jonah C Meltzer, Frieda Balduin, Bobby Beaumont, Zhanyun Fan, Eduard A. Sergienko, Steve Olson, Michael R Jackson, Bradley T. Hyman

The paper develops BiTSA, a bioluminescence-based thermal stability assay, to characterize isoform-dependent thermal stability of ApoE variants in living cells and confirms that ApoE4 is less stable than ApoE3 in native tissue.

bioRxiv · Jun 11, 2026 · PreprintNeuroscience

Dynamic conformational ensembles of soluble Tau encode neuronal toxicity prior to aggregation

Florian Georgescauld, Sonia Okekenwa, Tanner Boyd, Cameron Donahue, Noé Quittot, John R. Dickson, Zhanyun Fan, Scott Brady, Craig D. Blackstone, Bradley T. Hyman, Yuyu Song

This study identifies dynamic conformational states of soluble Tau that precede aggregation and correlate with neuronal toxicity in Alzheimer's disease and related tauopathies.

bioRxiv · Jan 27, 2026 · PreprintNeuroscience

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid beta aggregates in vivo in a mouse model of Alzheimer's disease

María Calvo-Rodríguez, Elizabeth K. Kharitonova, Austin C. Snyder, Steven S. Hou, Maria Virtudes Sanchez-Mico, Sudeshna Das, Zhanyun Fan, Hamid Shirani, K. Peter R. Nilsson, Alberto Serrano‐Pozo, Brian J. Bacskai

The paper uses real-time imaging to show increased mitochondrial oxidative stress in neurons near Aβ plaques in a mouse model of Alzheimer's disease, and demonstrates that this stress can be reduced by targeting calcium influx or using antioxidants.

bioRxiv · Jun 12, 2022 · PreprintNeuroscience

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

Eleanna Kara, Alessandro Crimi, Anne E. Wiedmer, Marc Emmenegger, Claudia Manzoni, Sara Bandrés‐Ciga, Karishma D’Sa, Regina Hertfelder Reynolds, Juan Antonio Botía, Marco Losa, Veronika Lysenko, Manfredi C. Carta, Daniel Heinzer, Merve Avar, Andra Chincisan, , Adriano Aguzzi

The paper identifies 38 genes regulating a-synuclein cell-to-cell transfer using an siRNA screen and shows genetic overlap with Parkinson's disease.

Cell Reports · Jun 1, 2021Peer-reviewedNeuroscience