Sophie Longueville

This study uses mouse models to investigate the role of Gnal loss in specific striatal projection neurons, revealing distinct effects on motor behavior and drug responses.

This study examines PYK2 levels and effects of its restoration in the striatum of HD mouse models and human patients, finding reduced levels but only partial improvement in motor phenotypes.

This study shows that inhibiting D1-receptor neurons reduces cocaine-induced locomotor activity and prevents sensitization after repeated cocaine exposure.

The paper describes a novel mouse model, Egr1-CreERT2, for permanently tagging neurons activated by seizures or cocaine, and shows that tagged neurons exhibit increased responsiveness to subsequent cocaine exposure.