Jean‐Antoine Girault

Molecular Basis and Cellular Effects of Janus-Class-Driven Cytoplasmic PYK2 Coacervates

This study identifies a novel mechanism of phase separation driven by the Janus-class KFL region of PYK2, showing its role in kinase activation and cell adhesion.

Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia

This study uses mouse models to investigate the role of Gnal loss in specific striatal projection neurons, revealing distinct effects on motor behavior and drug responses.

PYK2 in the dorsal striatum of Huntington disease R6/2 mouse model

This study examines PYK2 levels and effects of its restoration in the striatum of HD mouse models and human patients, finding reduced levels but only partial improvement in motor phenotypes.

Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.

This study investigates how adult-specific Reelin expression affects striatal neuronal organization and its implications for neuropsychiatric disorders using mouse models.

Hippocampal Egr1-dependent neuronal ensemblesnegatively regulate motor learning

The paper shows that Egr1-dependent hippocampal neuronal ensembles limit motor learning in mice.

Cell type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons

This study investigates the cell-type- and region-specific role of miR-1 in modulating cocaine-seeking behaviors in mice, showing distinct effects in D1- and D2-SPNs of the dorsal striatum.

Pyk2 in dorsal hippocampus plays a selective role in spatial memory and synaptic plasticity

This study shows that Pyk2 in the dorsal hippocampus is crucial for specific spatial memory tasks and synaptic plasticity, with effects dependent on experimental protocols.

Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine

This study shows that inhibiting D1-receptor neurons reduces cocaine-induced locomotor activity and prevents sensitization after repeated cocaine exposure.

Long-lasting tagging of neurons activated by seizures or cocaine administration in Egr1-CreERT2 transgenic mice

The paper describes a novel mouse model, Egr1-CreERT2, for permanently tagging neurons activated by seizures or cocaine, and shows that tagged neurons exhibit increased responsiveness to subsequent cocaine exposure.

Translational profiling of mouse dopaminoceptive neurons reveals a role of PGE2 in dorsal striatum

The paper identifies translational and splicing differences in dopaminoceptive neurons and highlights PGE2's role in enhancing D2 dopamine receptor function in the dorsal striatum.

fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons

This study uses chemogenetic activation of striatal neurons combined with fMRI to show increased thalamic and bilateral cortical activity and gamma-band oscillations.

Pyk2 in D1 receptor-expressing neurons of the nucleus accumbens modulates the acute locomotor effects of cocaine

This study shows that Pyk2 in D1 receptor-expressing neurons of the nucleus accumbens modulates acute cocaine-induced locomotor responses but not sensitization or place preference.