Mélody Labarchède

The paper uses genetically encoded voltage indicators to show that myelin depolarizes during neuronal activity, mediated by potassium channels, supporting axonal firing precision.

This study examines PYK2 levels and effects of its restoration in the striatum of HD mouse models and human patients, finding reduced levels but only partial improvement in motor phenotypes.

The paper investigates the interaction between mature oligodendrocytes and blood vessels in the mouse brain, finding that ~17% of oligodendrocytes are in contact with capillaries and suggesting a role in vascular microenvironment.