Denis Hervé

This study uses mouse models to investigate the role of Gnal loss in specific striatal projection neurons, revealing distinct effects on motor behavior and drug responses.

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

A mouse model of DYT25 dystonia with a Gnal mutation shows altered cerebello-thalamic plasticity, which can be modulated by theta-burst stimulation to reduce dystonia severity.

This study shows that inhibiting D1-receptor neurons reduces cocaine-induced locomotor activity and prevents sensitization after repeated cocaine exposure.

The paper describes a novel mouse model, Egr1-CreERT2, for permanently tagging neurons activated by seizures or cocaine, and shows that tagged neurons exhibit increased responsiveness to subsequent cocaine exposure.

The paper identifies translational and splicing differences in dopaminoceptive neurons and highlights PGE2's role in enhancing D2 dopamine receptor function in the dorsal striatum.

This study uses chemogenetic activation of striatal neurons combined with fMRI to show increased thalamic and bilateral cortical activity and gamma-band oscillations.