Author

Sophie Machata

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

Anastasia Bednarz· 3 shared Bachuki ShashikadzeiD· 3 shared Bjoern Schwalb· 3 shared Denis Bartoschek· 3 shared Henrik DaubiD· 3 shared Martin StegeriD· 3 shared Tobias Graef· 3 shared Uli OhmayeriD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Anastasia Bednarz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of CDK4-selective molecular glue degraders by high-throughput proteomics

Patrick R. A. Zanon, Bachuki Shashikadze, Denise Winkler, Ines F. Scheller, Denis Bartoschek, Anastasia Bednarz, Tobias Graef, Sophie Machata, Uli Ohmayer, Bjoern Schwalb, Martin Steger, Henrik Daub

This study identifies a CDK4-selective molecular glue degrader, NE26394, using high-throughput proteomics, showing its efficacy in CDK4-dependent cancer models.

bioRxiv · Jun 22, 2026 · PreprintBiochemistry

Integrated proteomic screening reveals design principles of CRBN molecular glue degraders

Bachuki Shashikadze, Ines F. Scheller, Denise Winkler, Patrick R. A. Zanon, Anastasia Bednarz, Denis Bartoschek, Sophie Machata, Tobias Graef, Uli Ohmayer, Bjoern Schwalb, Henrik Daub, Martin Steger

The paper identifies new CRBN neosubstrates using proteomic screening and machine learning, expanding the landscape of molecular glue degraders.

bioRxiv · Mar 10, 2026 · PreprintBiochemistry

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

Martin Steger, Gisele Nishiguchi, Qiong Wu, Bjoern Schwalb, Bachuki Shashikadze, Kevin M. McGowan, Marisa Actis, Anup Aggarwal, Zhe Shi, Jeanine E. Price, Anand Mayasundari, Lei Yang, Anastasia Bednarz, Sophie Machata, Tobias Graef, , Zoran Ranković

Proteomics and ubiquitinomics screening of 100 CRBN ligands in two cell lines validated 50 novel neosubstrates and yielded selective phenyl glutarimide degraders of KDM4B, G3BP2 and VCL.

Nature Communications · Aug 20, 2025Peer-reviewedBiochemistry✦ In-depth digest