Hepatocyte expression of fetal insulin receptor isoform contributes to the promotion of liver cancer through non-cell autonomous mechanisms
Fanny Léandre, Akila Iddir, Cécile Godard, Isabelle Lagoutte, Anthony Caldiero, Soumeya Souid, Sandra Pinto, Jérémy Augustin, Vanessa Bou Malham, Alexandre Alves, Rowan Aubry, Sandrine Imbeaud, Jessica Zucman‐Rossi, Sabine Colnot, Angélique Gougèlet, Christèle Desbois‐Mouthon
This study shows that hepatocyte expression of fetal insulin receptor isoform INSR-A promotes liver cancer through non-cell autonomous mechanisms by increasing inflammation and enabling preneoplastic cell proliferation.
bioRxiv · Jun 2, 2025 · PreprintCancer Biology