Jessica Zucman‐Rossi

This study shows BAP1 regulates liver homeostasis and tumor suppression by modulating ER stress and DDIT3 expression in response to metabolic stress.

This study shows that hepatocyte expression of fetal insulin receptor isoform INSR-A promotes liver cancer through non-cell autonomous mechanisms by increasing inflammation and enabling preneoplastic cell proliferation.

This study uses SpliceAI to identify cryptic splice mutations in cancer, finding over 100,000 such mutations across 18,115 tumors and uncovering new candidate driver genes.

MS.liverK is an R package that implements tools for computing molecular subtypes and functional signatures in liver cancer using transcriptome data.