Lipid mobilization establishes metabolic tolerance and prevents autonomic collapse in infection
Ankita Sarkar, Shangkui Xie, Syed Kazim Rizvi, Tadiwanashe Gwatiringa, Sophie Heston, Samuel Piaker, Narges Alipanah, Jianyi Yin, Laurent Gautron, Soumya Kamath, Neena Alex, Ashutosh Shukla, Lin Jia, Rani Shiao, Lauren E Kemp, , Suraj J. Patel
This study identifies white adipose tissue lipolysis and circulating fatty acids as key mediators of metabolic tolerance to infection, showing improved survival in sepsis with beta3-adrenergic agonists.
bioRxiv · Apr 21, 2026 · PreprintPhysiology