Author

Rani Shiao

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Anoj IlangesiD· 2 shared Aditya VasaniD· 1 shared Ahana ChakrabortyiD· 1 shared Alexander M. TataraiD· 1 shared An Kim· 1 shared Anders NelsoniD· 1 shared Anduena Toci· 1 shared Angela J. RogersiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersNeuroscience

Anoj IlangesORCID

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Author profile →

4 papers

Recent·Most cited

Single-cell multi-omics identify OTP and NOVA1 as regulators of leptin action in hypothalamic feeding circuits

Han L. Tan, Yuqi Tan, Jenelys Ruiz-Ortiz, Matt Paul, Zhaoyu Han, Leah Kelly, Anduena Toci, Kaja Plucinska, Yoko Tajima, Rani Shiao, Bora Lee, Anoj Ilanges, Robert B Darnell, Paul Cohen, Jeffrey M. Friedman

This study uses single-cell multi-omics to identify OTP and NOVA1 as key regulators of leptin action in hypothalamic feeding circuits, revealing cell-type-specific transcriptional and regulatory changes.

bioRxiv · Nov 6, 2026 · PreprintNeuroscience

Lipid mobilization establishes metabolic tolerance and prevents autonomic collapse in infection

Ankita Sarkar, Shangkui Xie, Syed Kazim Rizvi, Tadiwanashe Gwatiringa, Sophie Heston, Samuel Piaker, Narges Alipanah, Jianyi Yin, Laurent Gautron, Soumya Kamath, Neena Alex, Ashutosh Shukla, Lin Jia, Rani Shiao, Lauren E Kemp, , Suraj J. Patel

This study identifies white adipose tissue lipolysis and circulating fatty acids as key mediators of metabolic tolerance to infection, showing improved survival in sepsis with beta3-adrenergic agonists.

bioRxiv · Apr 21, 2026 · PreprintPhysiology

Corticothalamic Neurons in Motor Cortex Have a Permissive Role in Motor Execution

Lina Marcela Carmona, Anders Nelson, Lin T. Tun, An Kim, Rani Shiao, Michael D. Kissner, Vilas Menon, Rui M. Costa

The paper identifies corticothalamic neurons in the motor cortex as having a permissive role in motor execution by suppressing inhibition of corticospinal neurons during movement.

Nature Communications · May 21, 2025Peer-reviewedNeuroscience

Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

Marc Duque, Corinne A. Lee-Kubli, Yusuf Tufail, Uri Magaram, Janki Patel, Ahana Chakraborty, Jose Mendoza Lopez, Eric Edsinger, Aditya Vasan, Rani Shiao, Connor Weiss, James Robert Friend, Sreekanth H. Chalasani

This paper demonstrates that expressing human TRPA1 channels in neurons allows ultrasound to control neural activity in the intact mammalian brain.

Nature Communications · Feb 9, 2022Peer-reviewedNeuroscience