Jianyi Yin

This study shows that the CCC complex regulates PI(3)P levels on phagosomal membranes, which is critical for phagosome maturation and antibacterial immunity.

This study shows B3GNT7 regulates colonic mucus glycosylation, protects against colitis and infection, and has a distinct function from other B3GNT family members.

This study identifies white adipose tissue lipolysis and circulating fatty acids as key mediators of metabolic tolerance to infection, showing improved survival in sepsis with beta3-adrenergic agonists.

This study shows that type I interferon signaling promotes mucosal inflammation in colitis models, with IFNAR1 inhibition protecting against experimental colitis.