Fetal lung vascular development is disrupted by mechanical compression and rescued by administration of amniotic fluid stem cell extracellular vesicles via regulation of the Hippo signaling pathway.
Rebeca Lopes Figueira, Kasra Khalaj, Lina Antounians, Fabian Doktor, Maria Sole Gaffi, Mikal Obed, Sree Gandhi, Augusto Zani
This study shows mechanical compression disrupts fetal lung vascular development in CDH, but amniotic fluid stem cell extracellular vesicles reverse these effects via Hippo signaling pathway modulation.
bioRxiv · Nov 30, 2023 · PreprintDevelopmental Biology