Rebeca Lopes Figueira

Amniotic fluid stem cell extracellular vesicles promote lung development via TGF-beta modulation in a fetal rat model of oligohydramnios

This study shows that amniotic fluid stem cell extracellular vesicles improve lung development in a fetal rat model of oligohydramnios by modulating TGF-beta signaling through miR-93-5p.

Fetal lung vascular development is disrupted by mechanical compression and rescued by administration of amniotic fluid stem cell extracellular vesicles via regulation of the Hippo signaling pathway.

This study shows mechanical compression disrupts fetal lung vascular development in CDH, but amniotic fluid stem cell extracellular vesicles reverse these effects via Hippo signaling pathway modulation.

Administration of amniotic fluid stem cell extracellular vesicles promotes development of fetal hypoplastic lungs by immunomodulating lung macrophages

Amniotic fluid stem cell extracellular vesicles improve fetal lung development in CDH by modulating macrophage inflammation and restoring normal gene expression.

Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles

The paper shows that amniotic fluid stem cell extracellular vesicles restore autophagy in hypoplastic lungs, improving branching morphogenesis in rodent and human models.

Amniotic fluid stem cell extracellular vesicles promote fetal lung branching and cell differentiation in experimental congenital diaphragmatic hernia

This study shows that amniotic fluid stem cell extracellular vesicles rescue lung development in a rat model of congenital diaphragmatic hernia by restoring branching morphogenesis and cell differentiation.

Impaired Fetal Lung Development can be Rescued by Administration of Extracellular Vesicles Derived from Amniotic Fluid Stem Cells

The paper demonstrates that extracellular vesicles from amniotic fluid stem cells can rescue impaired fetal lung development in experimental models.