Author

Kasra Khalaj

Hospital for Sick ChildrenORCID 0000-0002-5947-6500Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:rat· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Augusto ZaniiD· 5 shared Lina AntouniansiD· 5 shared Rebeca Lopes FigueiraiD· 5 shared Fabian DoktoriD· 3 shared Mikal ObediD· 3 shared George BioussiD· 2 shared Louise MontalvaiD· 2 shared Sree Gandhi· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersDevelopmental Biology

Augusto ZaniORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Amniotic fluid stem cell extracellular vesicles promote lung development via TGF-beta modulation in a fetal rat model of oligohydramnios

Fabian Doktor, Rebeca Lopes Figueira, Victoria Fortuna, George Biouss, Kaya Stasiewicz, Mikal Obed, Kasra Khalaj, Lina Antounians, Augusto Zani

This study shows that amniotic fluid stem cell extracellular vesicles improve lung development in a fetal rat model of oligohydramnios by modulating TGF-beta signaling through miR-93-5p.

Journal of Controlled Release · Nov 26, 2024Peer-reviewedDevelopmental Biology

Fetal lung vascular development is disrupted by mechanical compression and rescued by administration of amniotic fluid stem cell extracellular vesicles via regulation of the Hippo signaling pathway.

Rebeca Lopes Figueira, Kasra Khalaj, Lina Antounians, Fabian Doktor, Maria Sole Gaffi, Mikal Obed, Sree Gandhi, Augusto Zani

This study shows mechanical compression disrupts fetal lung vascular development in CDH, but amniotic fluid stem cell extracellular vesicles reverse these effects via Hippo signaling pathway modulation.

bioRxiv · Nov 30, 2023 · PreprintDevelopmental Biology

Administration of amniotic fluid stem cell extracellular vesicles promotes development of fetal hypoplastic lungs by immunomodulating lung macrophages

Lina Antounians, Rebeca Lopes Figueira, Bharti Kukreja, Elke Zani‐Ruttenstock, Kasra Khalaj, Louise Montalva, Fabian Doktor, Mikal Obed, Matisse Blundell, Taiyi Wu, Cadia Chan, Richard Wagner, Martin Lacher, Michael D. Wilson, Brian Thomas Kalish, Augusto Zani

Amniotic fluid stem cell extracellular vesicles improve fetal lung development in CDH by modulating macrophage inflammation and restoring normal gene expression.

bioRxiv · Nov 29, 2022 · PreprintDevelopmental Biology

Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles

Kasra Khalaj, Lina Antounians, Rebeca Lopes Figueira, Martin Post, Augusto Zani

The paper shows that amniotic fluid stem cell extracellular vesicles restore autophagy in hypoplastic lungs, improving branching morphogenesis in rodent and human models.

American Journal of Respiratory and Critical Care Medicine · Jun 7, 2022Peer-reviewedDevelopmental Biology

Amniotic fluid stem cell extracellular vesicles promote fetal lung branching and cell differentiation in experimental congenital diaphragmatic hernia

Kasra Khalaj, Rebeca Lopes Figueira, Lina Antounians, Sree Gandhi, Matthew Wales, Louise Montalva, George Biouss, Augusto Zani

This study shows that amniotic fluid stem cell extracellular vesicles rescue lung development in a rat model of congenital diaphragmatic hernia by restoring branching morphogenesis and cell differentiation.

bioRxiv · Jan 10, 2022 · PreprintDevelopmental Biology