The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain.
Conny Leistner, Martin Wilkinson, Ailidh Burgess, Stanley Goodbody, Yong Xu, Susan A. Deuchars, Sheena E. Radford, Neil A. Ranson, René A. W. Frank
This study reveals the in-tissue molecular architecture of β-amyloid fibrils in a mouse model of Alzheimer's disease, showing their arrangement in lattices and their structural differences due to the Arctic mutation.
bioRxiv · Nov 8, 2022 · PreprintNeuroscience