Neil A. Ranson

This study determines the structure of herpes simplex virus 2 glycoprotein C interacting with C3b, revealing a unique mechanism to modulate the complement cascade.

This study uses cryo-EM to determine structural models of five intermediates in the maturation pathway of Nudaurelia capensis omega virus, revealing key structural changes during viral maturation.

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

The paper develops a high-throughput method to identify fluoroprobes that distinguish between tau fibril polymorphs using paDSF and chemical screening.

The paper describes a modified nanoparticle vaccine platform, N-VelcroVax, which effectively binds SUMO-tagged antigens and shows potential as a vaccine scaffold.

This study identifies residues 2-7 of alpha-synuclein as regulators of amyloid formation, showing they slow fibril formation and reduce aggregation in vitro and in vivo without affecting membrane binding.

This study reveals the in-tissue molecular architecture of β-amyloid fibrils in a mouse model of Alzheimer's disease, showing their arrangement in lattices and their structural differences due to the Arctic mutation.