ABCC6 and ANK regulate extracellular homeostasis of pyrophosphate and citrate and affect mineral deposition in bones and soft connective tissues
Flóra Szeri, Fatemeh Niaziorimi, Celina Ng, Cassandra Mikkelson, Ibtesam Rajpar, Qinglin Wu, Steven P. Matyus, Margery A. Connelly, George Tavadze, Stefan Lundkvist, Ryan E. Tomlinson, Koen van de Wetering
This study identifies ABCC6 and ANK as regulators of extracellular pyrophosphate and citrate, showing their roles in mineral deposition and bone health, with ANK also preventing soft tissue calcification.
bioRxiv · Oct 9, 2025 · PreprintDevelopmental Biology