Koen van de Wetering

This study shows phosphocitrate is more effective than pyrophosphate in reducing calcification in PXE mice, with better oral bioavailability and fewer side effects.

This study investigates ATP and AMPK homeostasis in a CMD mouse model, finding that AMPK inhibition restores osteoclast function and partially corrects skeletal abnormalities.

This study identifies ABCC6 and ANK as regulators of extracellular pyrophosphate and citrate, showing their roles in mineral deposition and bone health, with ANK also preventing soft tissue calcification.

This study shows that only very high oral doses of pyrophosphate inhibit ectopic calcification in Abcc6-/- mice, but these doses harm bone structure and are impractical for human use.

This study shows oral K3Citrate reduces disc calcification in LG/J mice without affecting bone structure or locomotion, suggesting Ca2+ chelation as a potential mechanism.

The paper investigates incomplete penetrance of the p.R391G ABCC6 variant in pseudoxanthoma elasticum, suggesting the need for an interacting partner for disease development.

This study identifies ANKH's role in extracellular citrate and pyrophosphate homeostasis and its impact on bone mechanical properties.