SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine
Pranay L. Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah Elizabeth Bell, Mallory Toci, Olivia K. Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud
This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.
bioRxiv · Mar 5, 2026 · PreprintBiochemistry