Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation.
Robin Bartolini, Deepika Sharma, Gillian J. Wilson, Gillian Dunphy, Jonathan Cavanagh, Jennifer A. Barrie, Heba A. Halawa, John J Cole, Stefan Weidt, Kirstyn Gardner-Stephen, Gerard J. Graham
This study shows that peripheral inflammation triggers fat pad atrophy and lymph node expansion via macrophage activity, supporting immune response energy needs.
bioRxiv · Oct 6, 2025 · PreprintImmunology