Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics
Jian Qiu, Martha A. Bosch, Mya S. Wolfe, Ksenija Korać, Stefano Rizzo, Todd L. Stincic, Scotland E. Farley, Wendy Fitzgerald, Megha Rajendran, Aurélien Laguerre, Frank Stein, Philip F. Copenhaver, Oline K. Rønnekleiv, Sean M. Ronnekleiv‐Kelly, Tatiana K. Rostovtseva, , Martin J. Kelly
This study identifies STX, a non-steroidal estrogenic compound, as targeting mitochondrial VDAC2 to enhance bioenergetics and provide neuroprotection in hypothalamic POMC neurons.
bioRxiv · Aug 21, 2026 · PreprintNeuroscience