Sean M. Ronnekleiv‐Kelly

This study identifies STX, a non-steroidal estrogenic compound, as targeting mitochondrial VDAC2 to enhance bioenergetics and provide neuroprotection in hypothalamic POMC neurons.

This study uses single-cell RNA sequencing to show that circadian clocks are aligned across liver cell populations and identifies cell-specific circadian regulated pathways.

This study develops a mouse model of DNAJB1-PRKACA fusion and shows it drives biliary and pancreatic carcinogenesis, with pre-invasive features and Slc16a14 as a biomarker for malignant transformation.

The paper introduces ORPHEUS, a method to quantify circadian desynchrony in single-cell data, finding reduced synchrony in AD-affected human brain excitatory neurons.

This study uses single-nucleus multi-omics to analyze fibrolamellar carcinoma, revealing rewired cell communication and potential therapeutic targets.