Cell BiologyNature CommunicationsPeer-reviewed
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Gregory Austin, Affiong I Oqua, Liliane El Eid…·Alejandra Tomás
This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.
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