Ben J. Jones

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

This paper describes the synthesis and properties of a novel dual GLP-1R/GIPR agonist, HISHS-2001, showing improved pharmacological profile compared to tirzepatide in vitro and in vivo.

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

This study identifies and validates cholesterol binding sites on GLP-1R in pancreatic beta cells, showing their role in receptor function and potential for drug design.

This study evaluates the impact of an N-terminal Halo-tag on GIPR function in mice, finding reduced cAMP responses and impaired glucose tolerance in tagged mice.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

This study performs a GWAS on random glucose measurements in 493,036 individuals, identifying 128 loci associated with glycaemic traits and providing insights into diabetes biology and treatment.