Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cellgenomics
Jessica E. Rexach, Yuyan Cheng, Lawrence Chen, Damon Polioudakis, Li‐Chun Lin, Vivianne Mitri, Andrew G. Elkins, Anna Yin, Daniela Calini, Riki Kawaguchi, Jing Ou, Jerry I. Huang, Christopher Williams, John L. Robinson, Stephanie E. Gaus, , Daniel H. Geschwind
The paper uses single-cell genomics to identify shared and disease-specific cell states and gene regulatory networks in three dementias, revealing distinct neuroimmune mechanisms and potential therapeutic targets.
bioRxiv · Sep 29, 2023 · PreprintNeuroscience