Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues.
Jonathan D. Douros, Megan E. Capozzi, Aaron Novikoff, Jacek Mokrosiński, BARENT N. DUBOIS, Joseph Stock, Rebecca Rohlfs, Mikayla Anderson, Dominika J Jedrzejcyk, Svend Poulsen, Erik Oude Blenke, Tomas Dago, Kasper Huus, Peder Lisby Nørby, Sune Kobberup, , Patrick J. Knerr
The paper shows that combining GLP-1R agonists with ectopic hepatic GLP-1R expression enhances weight loss in mice by increasing energy expenditure and reducing food intake.
Molecular Metabolism · Feb 5, 2026Peer-reviewedZoology