Jonathan R. Epp

Parity and APOEε4 genotype contribute distinct changes to functional connectivity across the middle-aged brain

This study examines how parity and APOEε4 genotype affect functional connectivity and cognitive outcomes in middle-aged rats.

Genetic variants disrupting activity-dependent CELF2 shuttling cause neuronal hyperexcitability, learning deficits, and seizures.

The paper identifies CELF2 variants causing cytoplasmic mislocalization linked to neuronal hyperexcitability, learning deficits, and seizures.

Inhibitory Circuit Compensations in Female and Male Mice: Increased Synaptic Output Offsets Reduced Parvalbumin Interneuron Density

The paper investigates sex differences in parvalbumin interneurons in healthy mice, finding females have fewer but more active and plastic inhibitory neurons in the retrosplenial cortex.

Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer's disease

The paper identifies sex-dependent impairments in parvalbumin interneurons in the retrosplenial cortex as a cause of cognitive deficits in Alzheimer's disease and suggests targeting these neurons as a therapeutic strategy.

Cognitive enrichment preserves retrosplenial parvalbumin density and cognitive function in female 5xFAD mice

The paper shows that enriched housing improves cognitive function and preserves parvalbumin interneurons in 5xFAD mice, with perineuronal nets protecting these neurons from amyloid toxicity.

Long-term impact of early life stress on serotonin connectivity

This study investigates how early life stress affects serotonin connectivity in mice, finding disruptions in brain-wide serotonin activity and anxiety-like behaviors in adulthood.

Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

The paper shows that hippocampal neurogenesis remodeling causes forgetting by altering engram accessibility, using genetic and optogenetic manipulations in mice.

Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction

This study investigates the role of hypocretin neurons in social behavior using fiber photometry and optogenetics in mice, revealing sex-dependent effects on social interaction.

Classifying high-dimensional phenotypes with ensemble learning

The paper evaluates ensemble learning for classifying high-dimensional phenotypes across 20 datasets, finding ensemble models improve accuracy by up to 3% over individual learners.

Brain-wide neuronal activation and functional connectivity are modulated by prior exposure to repetitive learning episodes.

This study shows that prior spatial training reduces brain-wide activation and increases functional connectivity efficiency and resilience during contextual fear memory recall in mice.

Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated activity

This study shows that low-intensity rTMS modulates brain-wide functional connectivity and neuronal activity, with anti-correlated effects in the amygdala and striatum.

Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval

This study shows that increased adult hippocampal neurogenesis reduces CA1 neuronal activity during context fear memory retrieval and alters perineuronal net expression, potentially leading to memory forgetting.

New neurons in old brains: A cautionary tale for the analysis of neurogenesis in post-mortem tissue.

This study shows that delayed tissue fixation in post-mortem rats reduces observed neurogenesis, suggesting fixation methods may explain apparent differences in human versus rodent neurogenesis.

Adult neurogenesis mediates forgetting of multiple types of memory in the rat

This study shows that increased neurogenesis in rats leads to forgetting of multiple types of hippocampus-dependent memories across different tasks.