Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase
Shireen S. Ganapathi, Emma D. Wrenn, Nicolas M. Garcia, Neerja Katiyar, Stephanie I Walter, Aya Miyaki, Jonah R. Valenti, Yuqi Kang, Marina Chan, Taranjit S. Gujral, Elizabeth R. Lawlor
This study shows that BET inhibitor treatment rewires Ewing sarcoma transcription, increasing dependency on FAK, and that combining BET and FAK inhibitors synergistically reduces tumor growth.
bioRxiv · Sep 2, 2025 · PreprintCancer Biology