Marina Chan

Neuroepithelial reprogramming and ERBB vulnerability in canine acanthomatous ameloblastoma

This study uses single-nucleus RNA-seq to identify unique neuroepithelial features in canine acanthomatous ameloblastoma, revealing ERBB4 as a therapeutic target.

A Systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas

This study identifies MERTK as a therapeutic target in ZFTA-RELA-driven ependymomas through transcriptomic analysis and drug screening.

Subtype-Specific Dependencies and Drug Vulnerabilities Enable Precision Therapeutics in Head and Neck Cancer

The paper identifies subtype-specific dependencies and drug vulnerabilities in HNSCC to enable precision therapeutics using transcriptomic and CRISPR data.

Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase

This study shows that BET inhibitor treatment rewires Ewing sarcoma transcription, increasing dependency on FAK, and that combining BET and FAK inhibitors synergistically reduces tumor growth.

Single-cell multi-omic analysis of fibrolamellar carcinoma reveals rewired cell-to-cell communication patterns and unique vulnerabilities

This study uses single-nucleus multi-omics to analyze fibrolamellar carcinoma, revealing rewired cell communication and potential therapeutic targets.

Functional evaluation of microdissected tumor 'cuboids': a microscale ex vivo cancer model that retains a complex tumor microenvironment

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

KinCytE- a Kinase to Cytokine Explorer to Identify Molecular Regulators and Potential Therapeutic Opportunities

KinCytE links kinase inhibitors to cytokine/chemokine signaling networks to identify therapeutic opportunities for difficult-to-drug targets.

Machine Learning Identifies Ponatinib as a Potent Inhibitor of SARS-CoV2-induced Cytokine Storm

The paper identifies Ponatinib as a potent inhibitor of cytokine storm induced by SARS-CoV-2 spike protein NTD in human cells.