Author
Seattle Children's Research InstituteORCID 0009-0008-6748-4595Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Emma D. Wrenn, Jacob C Harris, April Ann Apfelbaum…·Elizabeth R. Lawlor
The paper identifies TGFβ2 as a driver of a hybrid transcriptional state in Ewing sarcoma cells, promoting metastasis through ECM deposition and invasion.
Shireen S. Ganapathi, Emma D. Wrenn, Nicolas M. Garcia…·Elizabeth R. Lawlor
This study shows that BET inhibitor treatment rewires Ewing sarcoma transcription, increasing dependency on FAK, and that combining BET and FAK inhibitors synergistically reduces tumor growth.
Matthew R. Hathaway, Katherine E. Gadek, H. L. Jagana…·Myron K. Evans
This study identifies CTPS1 as a vulnerability in MYC-driven medulloblastoma and shows that combining CTPS1 and CHK1 inhibition synergistically reduces tumor growth in vivo.