This study shows Menin inhibition reduces metastatic colonization of Ewing sarcoma in vivo by disrupting MYC target gene expression and Menin:MYC interactions.

JCI Insight · Sep 1, 2026Peer-reviewedCancer Biology

Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma

Emma D. Wrenn, Jacob C Harris, April Ann Apfelbaum, Jonah R. Valenti, Patricia A. Lipson, Stephanie I. Walter, Nicolas M. Garcia, Aya Miyaki, Steven C. Chen, Jim M. Olson, Jason P. Price, Kelly M. Bailey, Elizabeth R. Lawlor

The paper identifies TGFβ2 as a driver of a hybrid transcriptional state in Ewing sarcoma cells, promoting metastasis through ECM deposition and invasion.

Science Advances · Jan 21, 2026Peer-reviewedCancer Biology

Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase

Shireen S. Ganapathi, Emma D. Wrenn, Nicolas M. Garcia, Neerja Katiyar, Stephanie I Walter, Aya Miyaki, Jonah R. Valenti, Yuqi Kang, Marina Chan, Taranjit S. Gujral, Elizabeth R. Lawlor

This study shows that BET inhibitor treatment rewires Ewing sarcoma transcription, increasing dependency on FAK, and that combining BET and FAK inhibitors synergistically reduces tumor growth.

bioRxiv · Sep 2, 2025 · PreprintCancer Biology

Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma.

Olivia G. Waltner, April Ann Apfelbaum, Emma D. Wrenn, Shruti S. Bhise, Sami B. Kanaan, Rula Green Gladden, Mark A Mendoza, Roger Volden, Zev N. Kronenberg, Anand G. Patel, Michael A. Dyer, Jay F. Sarthy, Elizabeth R. Lawlor, Scott N. Furlan

The paper identifies distinct transcriptional programs in Ewing sarcoma driven by EWS::FLI1 fusions and shows their variability across tumors and cell lines.

bioRxiv · Jun 18, 2025 · PreprintGenomics